藥物交互作用
Diatrizoate meglumine / diatrizoate + Glipizide-metformin
嚴重程度: 嚴重
Diatrizoate meglumine / diatrizoate and Glipizide-metformin: major interaction.
最後更新
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摘要
Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance. Metformin accumulation can then precipitate lactic acidosis, a rare but serious complication.
用白話說明這項交互作用的意義
Diatrizoate meglumine / diatrizoate and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Contrast-associated acute kidney injury reduces renal elimination of metformin, leading to accumulation and lactic acidosis.
處置方式
Hold metformin at the time of or before the procedure in patients with eGFR below 30, acute kidney injury or intra-arterial contrast with renal exposure. Restart about 48 hours later only after renal function has been re-checked and is stable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glipizide-metformin 的其他交互作用
常見問題
Can I take Diatrizoate meglumine / diatrizoate with Glipizide-metformin?
MediHelp rates the interaction as major. Diatrizoate meglumine / diatrizoate and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravascular iodinated contrast can cause acute kidney injury, which reduces metformin clearance. Metformin accumulation can then precipitate lactic acidosis, a rare but serious complication.
How serious is the interaction between Diatrizoate meglumine / diatrizoate and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with eGFR below 30, acute kidney injury or intra-arterial contrast with renal exposure. Restart about 48 hours later only after renal function has been re-checked and is stable.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate, Diazoxide. The full list is on the Glipizide-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
