藥物交互作用
Ethiodized oil + Glipizide-metformin
嚴重程度: 嚴重
Ethiodized oil and Glipizide-metformin: major interaction.
最後更新
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摘要
Ethiodized oil is an iodinated contrast agent. When given intravascularly (for example lymphography or chemoembolization) it may be associated with renal impairment and thereby reduce metformin clearance, with risk of lactic acidosis.
用白話說明這項交互作用的意義
Ethiodized oil and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Contrast-associated kidney injury reduces renal elimination of metformin, leading to accumulation and lactic acidosis.
處置方式
Hold metformin around intravascular administration in patients with eGFR below 30 or acute kidney injury. Restart after about 48 hours once renal function is confirmed stable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glipizide-metformin 的其他交互作用
常見問題
Can I take Ethiodized oil with Glipizide-metformin?
MediHelp rates the interaction as major. Ethiodized oil and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethiodized oil is an iodinated contrast agent. When given intravascularly (for example lymphography or chemoembolization) it may be associated with renal impairment and thereby reduce metformin clearance, with risk of lactic acidosis.
How serious is the interaction between Ethiodized oil and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin around intravascular administration in patients with eGFR below 30 or acute kidney injury. Restart after about 48 hours once renal function is confirmed stable.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
