藥物交互作用
Didanosine + Hydroxycarbamide
嚴重程度: 禁忌併用
Didanosine and Hydroxycarbamide: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Combining hydroxycarbamide with didanosine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, some fatal. The combination also appears to worsen immunologic outcomes in HIV.
用白話說明這項交互作用的意義
Didanosine and Hydroxycarbamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Hydroxycarbamide belongs to Oncology.
為什麼會發生
Overlapping toxicities, with hydroxycarbamide possibly increasing didanosine active metabolite activity and mitochondrial toxicity.
處置方式
Avoid the combination and use alternative antiretrovirals without these toxicities. Monitor lipase, liver enzymes and neurologic symptoms if prior exposure occurred.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Hydroxycarbamide 的其他交互作用
Didanosine 的其他交互作用
常見問題
Can I take Didanosine with Hydroxycarbamide?
MediHelp rates the interaction as contraindicated. Didanosine and Hydroxycarbamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining hydroxycarbamide with didanosine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, some fatal. The combination also appears to worsen immunologic outcomes in HIV.
How serious is the interaction between Didanosine and Hydroxycarbamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternative antiretrovirals without these toxicities. Monitor lipase, liver enzymes and neurologic symptoms if prior exposure occurred.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Stavudine. The full list is on the Hydroxycarbamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
