藥物交互作用
Dienogest / estradiol valerate + Griseofulvin
嚴重程度: 嚴重
Dienogest / estradiol valerate and Griseofulvin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Griseofulvin may lower estradiol and dienogest concentrations through enzyme induction, and it has been associated with contraceptive failure and breakthrough bleeding. Reduced hormone exposure may compromise contraceptive reliability.
用白話說明這項交互作用的意義
Dienogest / estradiol valerate and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Induction of CYP3A4 by griseofulvin increases metabolism of estradiol and dienogest.
處置方式
Advise an additional non-hormonal contraceptive method during griseofulvin treatment and for about 28 days after stopping it.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Griseofulvin 的其他交互作用
常見問題
Can I take Dienogest / estradiol valerate with Griseofulvin?
MediHelp rates the interaction as major. Dienogest / estradiol valerate and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may lower estradiol and dienogest concentrations through enzyme induction, and it has been associated with contraceptive failure and breakthrough bleeding. Reduced hormone exposure may compromise contraceptive reliability.
How serious is the interaction between Dienogest / estradiol valerate and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during griseofulvin treatment and for about 28 days after stopping it.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
