藥物交互作用
Griseofulvin + Lapatinib
嚴重程度: 嚴重
Griseofulvin and Lapatinib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Griseofulvin may considerably lower lapatinib exposure, which could compromise anticancer efficacy. Lapatinib is a CYP3A4 substrate whose levels fall markedly with inducers.
用白話說明這項交互作用的意義
Griseofulvin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Griseofulvin belongs to Anti Fungals; Lapatinib belongs to Oncology.
為什麼會發生
Griseofulvin-mediated CYP3A4 induction increases lapatinib clearance.
處置方式
Prefer a non-inducing antifungal. If unavoidable, lapatinib dose escalation as per labeling for strong inducers should be considered with close monitoring of response and toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Griseofulvin 的其他交互作用
Lapatinib 的其他交互作用
常見問題
Can I take Griseofulvin with Lapatinib?
MediHelp rates the interaction as major. Griseofulvin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may considerably lower lapatinib exposure, which could compromise anticancer efficacy. Lapatinib is a CYP3A4 substrate whose levels fall markedly with inducers.
How serious is the interaction between Griseofulvin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antifungal. If unavoidable, lapatinib dose escalation as per labeling for strong inducers should be considered with close monitoring of response and toxicity.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
