藥物交互作用
Ethinylestradiol + Griseofulvin
嚴重程度: 嚴重
Ethinylestradiol and Griseofulvin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Griseofulvin may reduce the effectiveness of combined hormonal contraceptives, with reports of breakthrough bleeding and contraceptive failure. The effect is thought to arise from enzyme induction.
用白話說明這項交互作用的意義
Ethinylestradiol and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Griseofulvin induces hepatic CYP3A4, increasing metabolism of ethinylestradiol.
處置方式
Advise an additional non-hormonal contraceptive method during treatment and for at least one month after stopping griseofulvin. Consider an alternative antifungal where appropriate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Griseofulvin 的其他交互作用
常見問題
Can I take Ethinylestradiol with Griseofulvin?
MediHelp rates the interaction as major. Ethinylestradiol and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may reduce the effectiveness of combined hormonal contraceptives, with reports of breakthrough bleeding and contraceptive failure. The effect is thought to arise from enzyme induction.
How serious is the interaction between Ethinylestradiol and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during treatment and for at least one month after stopping griseofulvin. Consider an alternative antifungal where appropriate.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
