藥物交互作用
Desogestrel-ethinyl estradiol + Griseofulvin
嚴重程度: 嚴重
Desogestrel-ethinyl estradiol and Griseofulvin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined hormonal contraceptives. This may result in unintended pregnancy. Griseofulvin is also teratogenic, which heightens the importance of reliable contraception.
用白話說明這項交互作用的意義
Desogestrel-ethinyl estradiol and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desogestrel-ethinyl estradiol belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
為什麼會發生
Griseofulvin is thought to induce hepatic enzymes, including CYP3A4, increasing metabolism of contraceptive steroids.
處置方式
Use a reliable non-hormonal contraceptive method alongside or instead of the pill during griseofulvin treatment and for about a month afterward. Counsel the patient on breakthrough bleeding as a warning sign.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Desogestrel-ethinyl estradiol 的其他交互作用
Griseofulvin 的其他交互作用
常見問題
Can I take Desogestrel-ethinyl estradiol with Griseofulvin?
MediHelp rates the interaction as major. Desogestrel-ethinyl estradiol and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined hormonal contraceptives. This may result in unintended pregnancy. Griseofulvin is also teratogenic, which heightens the importance of reliable contraception.
How serious is the interaction between Desogestrel-ethinyl estradiol and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reliable non-hormonal contraceptive method alongside or instead of the pill during griseofulvin treatment and for about a month afterward. Counsel the patient on breakthrough bleeding as a warning sign.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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