藥物交互作用
Dihydroergotamine + Dronedarone
嚴重程度: 禁忌併用
Dihydroergotamine and Dronedarone: contraindicated interaction.
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摘要
Dronedarone inhibits CYP3A4 and can raise dihydroergotamine levels. Excess ergot exposure can cause severe vasospasm and peripheral or cerebral ischemia.
用白話說明這項交互作用的意義
Dihydroergotamine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Dronedarone belongs to Cardiovascular.
為什麼會發生
Inhibition of CYP3A4 reduces dihydroergotamine clearance.
處置方式
Avoid the combination; use a non-ergot migraine therapy such as a triptan if appropriate.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Dronedarone 的其他交互作用
Dihydroergotamine 的其他交互作用
常見問題
Can I take Dihydroergotamine with Dronedarone?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronedarone inhibits CYP3A4 and can raise dihydroergotamine levels. Excess ergot exposure can cause severe vasospasm and peripheral or cerebral ischemia.
How serious is the interaction between Dihydroergotamine and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-ergot migraine therapy such as a triptan if appropriate.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
