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藥物交互作用

Dihydroergotamine + Eletriptan

嚴重程度: 禁忌併用

Dihydroergotamine and Eletriptan: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要,並非醫療建議,亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.

用白話說明這項交互作用的意義

Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.

證據等級: High

為什麼會發生

Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects; dihydroergotamine is also a CYP3A4 substrate.

處置方式

Avoid together and separate by at least 24 hours. Use only one agent per attack.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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常見問題

Can I take Dihydroergotamine with Eletriptan?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.

How serious is the interaction between Dihydroergotamine and Eletriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid together and separate by at least 24 hours. Use only one agent per attack.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.

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