藥物交互作用
Diltiazem + Lonafarnib
嚴重程度: 禁忌併用
Diltiazem and Lonafarnib: contraindicated interaction.
最後更新
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摘要
Lonafarnib is a sensitive CYP3A4 substrate, and diltiazem as a moderate CYP3A4 inhibitor can substantially increase its exposure. This raises the risk of lonafarnib toxicity, including gastrointestinal effects, renal and hepatic toxicity, and QT-related concerns. Labeling advises against use with moderate or strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Diltiazem and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Diltiazem belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
為什麼會發生
Diltiazem inhibits CYP3A4, reducing the metabolic clearance of lonafarnib.
處置方式
Avoid the combination and select a non-CYP3A4-inhibiting alternative to diltiazem. If unavoidable, follow labeling dose-reduction guidance and monitor closely for toxicity.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Diltiazem 的其他交互作用
Lonafarnib 的其他交互作用
常見問題
Can I take Diltiazem with Lonafarnib?
MediHelp rates the interaction as contraindicated. Diltiazem and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and diltiazem as a moderate CYP3A4 inhibitor can substantially increase its exposure. This raises the risk of lonafarnib toxicity, including gastrointestinal effects, renal and hepatic toxicity, and QT-related concerns. Labeling advises against use with moderate or strong CYP3A4 inhibitors.
How serious is the interaction between Diltiazem and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-CYP3A4-inhibiting alternative to diltiazem. If unavoidable, follow labeling dose-reduction guidance and monitor closely for toxicity.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
