藥物交互作用
Apalutamide + Lonafarnib
嚴重程度: 禁忌併用
Apalutamide and Lonafarnib: contraindicated interaction.
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摘要
Lonafarnib is a sensitive CYP3A4 substrate, and a strong inducer like apalutamide can reduce its levels considerably, compromising efficacy.
用白話說明這項交互作用的意義
Apalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
為什麼會發生
Apalutamide induces CYP3A4, enhancing the metabolic clearance of lonafarnib.
處置方式
Do not use together; choose a different antiandrogen. If an inducer must be stopped, wait for induction to resolve before restarting full lonafarnib dosing as directed by labeling.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Apalutamide 的其他交互作用
Lonafarnib 的其他交互作用
常見問題
Can I take Apalutamide with Lonafarnib?
MediHelp rates the interaction as contraindicated. Apalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and a strong inducer like apalutamide can reduce its levels considerably, compromising efficacy.
How serious is the interaction between Apalutamide and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different antiandrogen. If an inducer must be stopped, wait for induction to resolve before restarting full lonafarnib dosing as directed by labeling.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
