藥物交互作用
Diltiazem + Ivabradine
嚴重程度: 禁忌併用
Diltiazem and Ivabradine: contraindicated interaction.
最後更新
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摘要
Diltiazem increases ivabradine exposure and also lowers heart rate itself. The combination can cause marked bradycardia, conduction block and related symptoms such as dizziness or syncope.
用白話說明這項交互作用的意義
Diltiazem and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Diltiazem belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
為什麼會發生
Moderate CYP3A4 inhibition raises ivabradine concentrations, with additive sinus node slowing from both drugs.
處置方式
Avoid the combination; labeling advises against ivabradine with diltiazem or verapamil. Choose an alternative antianginal or heart failure strategy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Diltiazem 的其他交互作用
Ivabradine 的其他交互作用
常見問題
Can I take Diltiazem with Ivabradine?
MediHelp rates the interaction as contraindicated. Diltiazem and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diltiazem increases ivabradine exposure and also lowers heart rate itself. The combination can cause marked bradycardia, conduction block and related symptoms such as dizziness or syncope.
How serious is the interaction between Diltiazem and Ivabradine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against ivabradine with diltiazem or verapamil. Choose an alternative antianginal or heart failure strategy.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Diltiazem page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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