藥物交互作用
Diphenoxylate-atropine + Tranylcypromine
嚴重程度: 禁忌併用
Diphenoxylate-atropine and Tranylcypromine: contraindicated interaction.
最後更新
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摘要
Diphenoxylate is labeled as potentially causing hypertensive crisis when given with MAO inhibitors. Tranylcypromine is a nonselective irreversible MAOI, so the risk of severe hypertension and agitation is substantial.
用白話說明這項交互作用的意義
Diphenoxylate-atropine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.
為什麼會發生
Irreversible MAO inhibition may potentiate the pressor and CNS effects of the opioid; the exact mechanism is not fully defined.
處置方式
Do not co-administer, and do not start diphenoxylate-atropine within 14 days of stopping tranylcypromine. Use a different antidiarrheal such as loperamide.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Diphenoxylate-atropine 的其他交互作用
Tranylcypromine 的其他交互作用
常見問題
Can I take Diphenoxylate-atropine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Diphenoxylate-atropine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diphenoxylate is labeled as potentially causing hypertensive crisis when given with MAO inhibitors. Tranylcypromine is a nonselective irreversible MAOI, so the risk of severe hypertension and agitation is substantial.
How serious is the interaction between Diphenoxylate-atropine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and do not start diphenoxylate-atropine within 14 days of stopping tranylcypromine. Use a different antidiarrheal such as loperamide.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Alfentanil. The full list is on the Diphenoxylate-atropine page.
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