藥物交互作用
Diphenoxylate-atropine + Isocarboxazid
嚴重程度: 禁忌併用
Diphenoxylate-atropine and Isocarboxazid: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Diphenoxylate is structurally related to meperidine, and MAO inhibitors can cause severe reactions with such opioids. Hypertensive crisis, hyperpyrexia, hypotension, somnolence or death may occur. Labeling advises against use of diphenoxylate with MAO inhibitors.
用白話說明這項交互作用的意義
Diphenoxylate-atropine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
MAO inhibition may potentiate diphenoxylate through a meperidine-like interaction; the exact mechanism is not fully established.
處置方式
Do not use together or within 14 days of stopping the MAO inhibitor. Use a non-opioid antidiarrheal alternative.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Diphenoxylate-atropine 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Diphenoxylate-atropine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Diphenoxylate-atropine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diphenoxylate is structurally related to meperidine, and MAO inhibitors can cause severe reactions with such opioids. Hypertensive crisis, hyperpyrexia, hypotension, somnolence or death may occur. Labeling advises against use of diphenoxylate with MAO inhibitors.
How serious is the interaction between Diphenoxylate-atropine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAO inhibitor. Use a non-opioid antidiarrheal alternative.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Phenelzine, Tranylcypromine, Alfentanil. The full list is on the Diphenoxylate-atropine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
