藥物交互作用
Amitriptyline + Diphenoxylate-atropine
嚴重程度: 嚴重
Amitriptyline and Diphenoxylate-atropine: major interaction.
最後更新
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摘要
Amitriptyline is strongly anticholinergic and sedating, and the atropine and diphenoxylate components add to this. The combination can cause constipation progressing to ileus, urinary retention, tachycardia, confusion and excess sedation.
用白話說明這項交互作用的意義
Amitriptyline and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
為什麼會發生
Additive muscarinic blockade and additive CNS depression.
處置方式
Avoid combining where possible, especially in older patients or those with ileus or urinary retention; if used, monitor bowel and bladder function and mental status.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Diphenoxylate-atropine 的其他交互作用
Amitriptyline 的其他交互作用
常見問題
Can I take Amitriptyline with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Amitriptyline and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline is strongly anticholinergic and sedating, and the atropine and diphenoxylate components add to this. The combination can cause constipation progressing to ileus, urinary retention, tachycardia, confusion and excess sedation.
How serious is the interaction between Amitriptyline and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in older patients or those with ileus or urinary retention; if used, monitor bowel and bladder function and mental status.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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