藥物交互作用
Doxorubicin + Trastuzumab
嚴重程度: 嚴重
Doxorubicin and Trastuzumab: major interaction.
最後更新
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摘要
Trastuzumab causes cardiac dysfunction, and doxorubicin causes cumulative dose-related cardiomyopathy. Combination or close sequencing markedly increases the incidence of heart failure and LVEF decline.
用白話說明這項交互作用的意義
Doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxorubicin belongs to Oncology; Trastuzumab belongs to Oncology.
為什麼會發生
Additive cardiotoxicity: anthracycline myocyte injury combined with inhibition of HER2-mediated cardioprotective signaling.
處置方式
Avoid concurrent use and allow a long interval after anthracycline therapy. Assess LVEF before and regularly during treatment, and withhold trastuzumab if significant decline occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Doxorubicin 的其他交互作用
Trastuzumab 的其他交互作用
常見問題
Can I take Doxorubicin with Trastuzumab?
MediHelp rates the interaction as major. Doxorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab causes cardiac dysfunction, and doxorubicin causes cumulative dose-related cardiomyopathy. Combination or close sequencing markedly increases the incidence of heart failure and LVEF decline.
How serious is the interaction between Doxorubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow a long interval after anthracycline therapy. Assess LVEF before and regularly during treatment, and withhold trastuzumab if significant decline occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
