藥物交互作用
Epirubicin + Trastuzumab
嚴重程度: 嚴重
Epirubicin and Trastuzumab: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Concurrent or sequential use of trastuzumab with anthracyclines such as epirubicin increases the incidence and severity of cardiomyopathy. Heart failure may develop and be clinically significant.
用白話說明這項交互作用的意義
Epirubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epirubicin belongs to Oncology; Trastuzumab belongs to Oncology.
為什麼會發生
Additive cardiotoxicity from anthracycline injury and HER2 pathway inhibition.
處置方式
Avoid concurrent use outside protocols with strict cardiac surveillance. Check LVEF at baseline and periodically, and hold therapy if LVEF declines significantly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Epirubicin 的其他交互作用
Trastuzumab 的其他交互作用
常見問題
Can I take Epirubicin with Trastuzumab?
MediHelp rates the interaction as major. Epirubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent or sequential use of trastuzumab with anthracyclines such as epirubicin increases the incidence and severity of cardiomyopathy. Heart failure may develop and be clinically significant.
How serious is the interaction between Epirubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use outside protocols with strict cardiac surveillance. Check LVEF at baseline and periodically, and hold therapy if LVEF declines significantly.
What other medicines interact with Epirubicin?
MediHelp also lists interactions of Epirubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cimetidine. The full list is on the Epirubicin page.
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