藥物交互作用
Idarubicin + Trastuzumab
嚴重程度: 嚴重
Idarubicin and Trastuzumab: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Trastuzumab-associated cardiomyopathy is more frequent and severe when combined with or given after anthracyclines. Idarubicin shares the cardiotoxic class effect, so the combination carries a significant risk of heart failure.
用白話說明這項交互作用的意義
Idarubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idarubicin belongs to Oncology; Trastuzumab belongs to Oncology.
為什麼會發生
Additive cardiotoxicity from anthracycline myocyte damage and HER2 signaling blockade.
處置方式
Avoid concurrent use where possible and check LVEF at baseline and regularly. Stop or hold treatment if LVEF drops or heart failure develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Idarubicin 的其他交互作用
Trastuzumab 的其他交互作用
常見問題
Can I take Idarubicin with Trastuzumab?
MediHelp rates the interaction as major. Idarubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab-associated cardiomyopathy is more frequent and severe when combined with or given after anthracyclines. Idarubicin shares the cardiotoxic class effect, so the combination carries a significant risk of heart failure.
How serious is the interaction between Idarubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and check LVEF at baseline and regularly. Stop or hold treatment if LVEF drops or heart failure develops.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
