藥物交互作用
Dronedarone + Fluconazole
嚴重程度: 禁忌併用
Dronedarone and Fluconazole: contraindicated interaction.
最後更新
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摘要
Fluconazole inhibits CYP3A4 and prolongs the QTc interval, and dronedarone adds its own QT effect. Higher dronedarone exposure and additive QT prolongation together raise torsades de pointes risk.
用白話說明這項交互作用的意義
Dronedarone and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
為什麼會發生
CYP3A4 inhibition plus additive QTc prolongation
處置方式
Do not co-administer; use a non-azole antifungal option or an alternative antiarrhythmic.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fluconazole 的其他交互作用
Dronedarone 的其他交互作用
常見問題
Can I take Dronedarone with Fluconazole?
MediHelp rates the interaction as contraindicated. Dronedarone and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole inhibits CYP3A4 and prolongs the QTc interval, and dronedarone adds its own QT effect. Higher dronedarone exposure and additive QT prolongation together raise torsades de pointes risk.
How serious is the interaction between Dronedarone and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-azole antifungal option or an alternative antiarrhythmic.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
