藥物交互作用
Dulaglutide + Empagliflozin-linagliptin
嚴重程度: 中度
Dulaglutide and Empagliflozin-linagliptin: moderate interaction.
最後更新
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摘要
Combining dulaglutide with empagliflozin and linagliptin gives additive glucose lowering. Linagliptin and dulaglutide both act on the incretin pathway, so adding a DPP-4 inhibitor to a GLP-1 agonist offers little extra benefit and adds cost and pill burden.
用白話說明這項交互作用的意義
Dulaglutide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Empagliflozin-linagliptin belongs to Endocrine.
為什麼會發生
Overlapping incretin-pathway activity plus additive antihyperglycemic effect of SGLT2 inhibition.
處置方式
Avoid routine combination of a DPP-4 inhibitor with a GLP-1 agonist. Monitor glucose, volume status and gastrointestinal tolerability.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Empagliflozin-linagliptin 的其他交互作用
Dulaglutide 的其他交互作用
常見問題
Can I take Dulaglutide with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Dulaglutide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining dulaglutide with empagliflozin and linagliptin gives additive glucose lowering. Linagliptin and dulaglutide both act on the incretin pathway, so adding a DPP-4 inhibitor to a GLP-1 agonist offers little extra benefit and adds cost and pill burden.
How serious is the interaction between Dulaglutide and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of a DPP-4 inhibitor with a GLP-1 agonist. Monitor glucose, volume status and gastrointestinal tolerability.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
