藥物交互作用
Duvelisib + Ergotamine
嚴重程度: 禁忌併用
Duvelisib and Ergotamine: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Ergotamine is cleared mainly by CYP3A4, and higher levels carry a risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
用白話說明這項交互作用的意義
Duvelisib and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duvelisib belongs to Oncology; Ergotamine belongs to Central Nervous System.
為什麼會發生
Duvelisib inhibits CYP3A4, reducing the first-pass and systemic metabolism of ergotamine.
處置方式
Avoid combining ergotamine with duvelisib and choose a non-ergot acute migraine treatment. If it cannot be avoided, monitor closely for ischemic symptoms such as cold or numb extremities and chest pain.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ergotamine 的其他交互作用
Duvelisib 的其他交互作用
常見問題
Can I take Duvelisib with Ergotamine?
MediHelp rates the interaction as contraindicated. Duvelisib and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Ergotamine is cleared mainly by CYP3A4, and higher levels carry a risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Duvelisib and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining ergotamine with duvelisib and choose a non-ergot acute migraine treatment. If it cannot be avoided, monitor closely for ischemic symptoms such as cold or numb extremities and chest pain.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
