藥物交互作用
Clarithromycin + Ergotamine
嚴重程度: 禁忌併用
Clarithromycin and Ergotamine: contraindicated interaction.
最後更新 來源: US FDA label
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摘要
Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.
用白話說明這項交互作用的意義
Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Ergotamine belongs to Central Nervous System.
為什麼會發生
Clarithromycin strongly inhibits CYP3A4, reducing the metabolism of ergotamine and causing excessive exposure and vasoconstriction.
處置方式
Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
Ergotamine 的其他交互作用
Clarithromycin 的其他交互作用
常見問題
Can I take Clarithromycin with Ergotamine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases ergotamine concentrations and has been associated with acute ergot toxicity, including severe vasospasm and ischemia of the extremities, central nervous system and heart. Serious ischemic complications have been reported, sometimes after only a few doses. Concomitant use is contraindicated in product labeling.
How serious is the interaction between Clarithromycin and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-interacting antibiotic such as azithromycin (weaker effect) or another class suited to the infection if an ergot is needed. Alternatively withhold ergotamine and treat migraine with a non-ergot agent while clarithromycin is given.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Cobicistat. The full list is on the Ergotamine page.
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