藥物交互作用
Doravirine + Efavirenz
嚴重程度: 禁忌併用
Doravirine and Efavirenz: contraindicated interaction.
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摘要
Efavirenz lowers doravirine concentrations, risking loss of virologic suppression and resistance. Both are NNRTIs and combining them offers no benefit.
用白話說明這項交互作用的意義
Doravirine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doravirine belongs to Anti Virals; Efavirenz belongs to Anti Virals.
為什麼會發生
Induction of CYP3A4 metabolism of doravirine by efavirenz.
處置方式
Do not combine; choose one NNRTI-based regimen. If switching, stop efavirenz and allow for its enzyme induction to wane, as advised in the labeling.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Efavirenz 的其他交互作用
Doravirine 的其他交互作用
常見問題
Can I take Doravirine with Efavirenz?
MediHelp rates the interaction as contraindicated. Doravirine and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz lowers doravirine concentrations, risking loss of virologic suppression and resistance. Both are NNRTIs and combining them offers no benefit.
How serious is the interaction between Doravirine and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose one NNRTI-based regimen. If switching, stop efavirenz and allow for its enzyme induction to wane, as advised in the labeling.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
