藥物交互作用
Cobimetinib + Efavirenz
嚴重程度: 禁忌併用
Cobimetinib and Efavirenz: contraindicated interaction.
最後更新
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摘要
Efavirenz induces CYP3A4 and can markedly lower cobimetinib exposure. This may lead to loss of antitumour efficacy.
用白話說明這項交互作用的意義
Cobimetinib and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobimetinib belongs to Oncology; Efavirenz belongs to Anti Virals.
為什麼會發生
Induction of CYP3A4-mediated metabolism of cobimetinib by efavirenz.
處置方式
Avoid the combination and use an alternative antiretroviral without enzyme-inducing properties. If it cannot be avoided, seek oncology and HIV specialist input.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Efavirenz 的其他交互作用
Cobimetinib 的其他交互作用
常見問題
Can I take Cobimetinib with Efavirenz?
MediHelp rates the interaction as contraindicated. Cobimetinib and Efavirenz are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz induces CYP3A4 and can markedly lower cobimetinib exposure. This may lead to loss of antitumour efficacy.
How serious is the interaction between Cobimetinib and Efavirenz?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiretroviral without enzyme-inducing properties. If it cannot be avoided, seek oncology and HIV specialist input.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Dienogest / estradiol valerate, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
