藥物交互作用
Elagolix + Ketoconazole
嚴重程度: 嚴重
Elagolix and Ketoconazole: major interaction.
最後更新
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摘要
Strong CYP3A inhibition by ketoconazole increases elagolix exposure, raising the risk of dose-related effects such as bone mineral density loss and liver enzyme elevations. Risk is greater with longer duration of use.
用白話說明這項交互作用的意義
Elagolix and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Ketoconazole belongs to Anti Fungals.
為什麼會發生
Ketoconazole inhibits CYP3A4-mediated metabolism of elagolix.
處置方式
Avoid long-term use with the 200 mg twice-daily dose; if the combination is needed, limit elagolix to 150 mg once daily and restrict the inhibitor course to a maximum of 6 months.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ketoconazole 的其他交互作用
Elagolix 的其他交互作用
常見問題
Can I take Elagolix with Ketoconazole?
MediHelp rates the interaction as major. Elagolix and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A inhibition by ketoconazole increases elagolix exposure, raising the risk of dose-related effects such as bone mineral density loss and liver enzyme elevations. Risk is greater with longer duration of use.
How serious is the interaction between Elagolix and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term use with the 200 mg twice-daily dose; if the combination is needed, limit elagolix to 150 mg once daily and restrict the inhibitor course to a maximum of 6 months.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
