藥物交互作用
Elagolix + Erythromycin
嚴重程度: 嚴重
Elagolix and Erythromycin: major interaction.
最後更新
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摘要
Erythromycin may increase elagolix exposure, raising the risk of adverse effects such as bone loss and liver enzyme elevations. Elagolix labeling restricts use with strong OATP1B1 inhibitors, and erythromycin has inhibitory activity on this transporter.
用白話說明這項交互作用的意義
Elagolix and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Erythromycin belongs to Anti Bacterial.
為什麼會發生
Inhibition of OATP1B1-mediated hepatic uptake (and CYP3A) increases elagolix concentrations.
處置方式
Avoid the combination where possible; use an alternative antibiotic such as azithromycin or doxycycline as appropriate. If unavoidable, limit duration and monitor for adverse effects.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Erythromycin 的其他交互作用
Elagolix 的其他交互作用
常見問題
Can I take Elagolix with Erythromycin?
MediHelp rates the interaction as major. Elagolix and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may increase elagolix exposure, raising the risk of adverse effects such as bone loss and liver enzyme elevations. Elagolix labeling restricts use with strong OATP1B1 inhibitors, and erythromycin has inhibitory activity on this transporter.
How serious is the interaction between Elagolix and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; use an alternative antibiotic such as azithromycin or doxycycline as appropriate. If unavoidable, limit duration and monitor for adverse effects.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
