藥物交互作用
Elagolix + Ethinyl estradiol-levonorgestrel
嚴重程度: 嚴重
Elagolix and Ethinyl estradiol-levonorgestrel: major interaction.
最後更新
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摘要
Elagolix suppresses the hypothalamic-pituitary-ovarian axis, and estrogen-containing contraceptives are expected to oppose its effect and reduce its efficacy. Elagolix is also not a reliable contraceptive when combined with hormonal methods, and its own effect on contraceptive efficacy is uncertain.
用白話說明這項交互作用的意義
Elagolix and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
為什麼會發生
Pharmacodynamic antagonism between exogenous estrogen/progestin and GnRH receptor antagonism by elagolix.
處置方式
Avoid combining the two drugs and use non-hormonal contraception during elagolix and for about one week after stopping. Reassess symptom control if hormonal contraception is considered necessary.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ethinyl estradiol-levonorgestrel 的其他交互作用
- Ethinyl estradiol-levonorgestrel + Fezolinetant 禁忌併用
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir 禁忌併用
- Ethinyl estradiol-levonorgestrel + Tranexamic acid 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel 嚴重
- Amobarbital + Ethinyl estradiol-levonorgestrel 嚴重
- Anastrozole + Ethinyl estradiol-levonorgestrel 嚴重
Elagolix 的其他交互作用
常見問題
Can I take Elagolix with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as major. Elagolix and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Elagolix suppresses the hypothalamic-pituitary-ovarian axis, and estrogen-containing contraceptives are expected to oppose its effect and reduce its efficacy. Elagolix is also not a reliable contraceptive when combined with hormonal methods, and its own effect on contraceptive efficacy is uncertain.
How serious is the interaction between Elagolix and Ethinyl estradiol-levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two drugs and use non-hormonal contraception during elagolix and for about one week after stopping. Reassess symptom control if hormonal contraception is considered necessary.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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