藥物交互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ivabradine
嚴重程度: 禁忌併用
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ivabradine: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
The cobicistat component strongly inhibits CYP3A4 and raises ivabradine exposure. This increases the risk of severe bradycardia and conduction disturbances.
用白話說明這項交互作用的意義
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Cobicistat-mediated CYP3A4 inhibition decreases ivabradine clearance.
處置方式
Do not co-administer. Use an alternative to ivabradine or switch to an antiretroviral regimen without a CYP3A4 booster.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ivabradine 的其他交互作用
常見問題
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ivabradine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The cobicistat component strongly inhibits CYP3A4 and raises ivabradine exposure. This increases the risk of severe bradycardia and conduction disturbances.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ivabradine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative to ivabradine or switch to an antiretroviral regimen without a CYP3A4 booster.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
