藥物交互作用
Darunavir + Ivabradine
嚴重程度: 禁忌併用
Darunavir and Ivabradine: contraindicated interaction.
最後更新
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摘要
Darunavir, particularly when boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and increases ivabradine levels. The result may be profound bradycardia and conduction block.
用白話說明這項交互作用的意義
Darunavir and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Ivabradine belongs to Cardiovascular.
為什麼會發生
CYP3A4 inhibition reduces ivabradine metabolism and increases exposure.
處置方式
Avoid concurrent use. Choose a different heart rate-lowering therapy while on a darunavir-based regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ivabradine 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Darunavir with Ivabradine?
MediHelp rates the interaction as contraindicated. Darunavir and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, particularly when boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and increases ivabradine levels. The result may be profound bradycardia and conduction block.
How serious is the interaction between Darunavir and Ivabradine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Choose a different heart rate-lowering therapy while on a darunavir-based regimen.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
