藥物交互作用

Ensitrelvir + Rifampicin

嚴重程度: 禁忌併用

Ensitrelvir and Rifampicin: contraindicated interaction.

最後更新 14 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Rifampicin strongly induces CYP3A and can markedly lower ensitrelvir plasma concentrations. Subtherapeutic exposure may cause loss of antiviral activity and treatment failure.

用白話說明這項交互作用的意義

Ensitrelvir and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ensitrelvir belongs to Anti Virals; Rifampicin belongs to Anti Bacterial.

證據等級: High

為什麼會發生

Rifampicin induces CYP3A (and transporters), accelerating ensitrelvir metabolism and lowering exposure.

處置方式

Do not co-administer; select an alternative COVID-19 antiviral not affected by strong inducers. If rifampicin is essential, avoid ensitrelvir.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Ensitrelvir 與 Rifampicin 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Ensitrelvir with Rifampicin?

MediHelp rates the interaction as contraindicated. Ensitrelvir and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin strongly induces CYP3A and can markedly lower ensitrelvir plasma concentrations. Subtherapeutic exposure may cause loss of antiviral activity and treatment failure.

How serious is the interaction between Ensitrelvir and Rifampicin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative COVID-19 antiviral not affected by strong inducers. If rifampicin is essential, avoid ensitrelvir.

What other medicines interact with Ensitrelvir?

MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.

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摘要