藥物交互作用
Isavuconazonium + Rifampicin
嚴重程度: 禁忌併用
Isavuconazonium and Rifampicin: contraindicated interaction.
最後更新
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摘要
Rifampicin strongly induces CYP3A4 and dramatically lowers isavuconazole exposure after isavuconazonium administration. This risks failure of therapy for invasive fungal infection.
用白話說明這項交互作用的意義
Isavuconazonium and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Rifampicin belongs to Anti Bacterial.
為什麼會發生
Potent induction of CYP3A4/5 by rifampicin increases isavuconazole clearance.
處置方式
Do not coadminister; use an alternative antimycobacterial agent or antifungal.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isavuconazonium 的其他交互作用
Rifampicin 的其他交互作用
常見問題
Can I take Isavuconazonium with Rifampicin?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin strongly induces CYP3A4 and dramatically lowers isavuconazole exposure after isavuconazonium administration. This risks failure of therapy for invasive fungal infection.
How serious is the interaction between Isavuconazonium and Rifampicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antimycobacterial agent or antifungal.
What other medicines interact with Isavuconazonium?
MediHelp also lists interactions of Isavuconazonium with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Isavuconazonium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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