藥物交互作用
Doravirine + Rifampicin
嚴重程度: 禁忌併用
Doravirine and Rifampicin: contraindicated interaction.
最後更新
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摘要
Rifampicin markedly reduces doravirine concentrations, which may lead to loss of antiviral efficacy and resistance. The combination is contraindicated in labeling.
用白話說明這項交互作用的意義
Doravirine and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doravirine belongs to Anti Virals; Rifampicin belongs to Anti Bacterial.
為什麼會發生
Rifampicin strongly induces CYP3A4, increasing doravirine clearance.
處置方式
Do not use together. Use an alternative TB regimen, such as rifabutin with a doravirine dose increase per labeling, or change the antiretroviral regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Doravirine 的其他交互作用
Rifampicin 的其他交互作用
常見問題
Can I take Doravirine with Rifampicin?
MediHelp rates the interaction as contraindicated. Doravirine and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin markedly reduces doravirine concentrations, which may lead to loss of antiviral efficacy and resistance. The combination is contraindicated in labeling.
How serious is the interaction between Doravirine and Rifampicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use an alternative TB regimen, such as rifabutin with a doravirine dose increase per labeling, or change the antiretroviral regimen.
What other medicines interact with Doravirine?
MediHelp also lists interactions of Doravirine with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Doravirine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
