藥物交互作用
Ergoloid mesylates + Sumatriptan
嚴重程度: 禁忌併用
Ergoloid mesylates and Sumatriptan: contraindicated interaction.
最後更新
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摘要
Both drugs can constrict blood vessels, so taking them close together may produce prolonged vasospasm and reduced blood flow to the heart, brain or limbs. Ergoloid mesylates has weaker vasoconstrictor activity than classic ergot alkaloids, but labeling for triptans still advises against combining them with ergot-type drugs.
用白話說明這項交互作用的意義
Ergoloid mesylates and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive vasoconstriction through 5-HT1B/1D agonism (triptan) and ergot-derived serotonergic and adrenergic receptor effects.
處置方式
Avoid concurrent use and keep at least 24 hours between a triptan and an ergot-type drug. Choose a single agent for the acute indication.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sumatriptan 的其他交互作用
常見問題
Can I take Ergoloid mesylates with Sumatriptan?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can constrict blood vessels, so taking them close together may produce prolonged vasospasm and reduced blood flow to the heart, brain or limbs. Ergoloid mesylates has weaker vasoconstrictor activity than classic ergot alkaloids, but labeling for triptans still advises against combining them with ergot-type drugs.
How serious is the interaction between Ergoloid mesylates and Sumatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep at least 24 hours between a triptan and an ergot-type drug. Choose a single agent for the acute indication.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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