藥物交互作用
Dihydroergotamine + Sumatriptan
嚴重程度: 禁忌併用
Dihydroergotamine and Sumatriptan: contraindicated interaction.
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摘要
Both drugs constrict blood vessels, and combined use can produce additive prolonged vasospasm with risk of coronary or peripheral ischemia. Labeling prohibits use of triptans and ergot derivatives within 24 hours of each other.
用白話說明這項交互作用的意義
Dihydroergotamine and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
為什麼會發生
Additive vasoconstriction via 5-HT1B/1D agonism by sumatriptan and serotonergic and adrenergic vasoconstriction by dihydroergotamine.
處置方式
Do not use within 24 hours of each other. Choose one agent for each migraine episode and observe the timing interval.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sumatriptan 的其他交互作用
Dihydroergotamine 的其他交互作用
常見問題
Can I take Dihydroergotamine with Sumatriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs constrict blood vessels, and combined use can produce additive prolonged vasospasm with risk of coronary or peripheral ischemia. Labeling prohibits use of triptans and ergot derivatives within 24 hours of each other.
How serious is the interaction between Dihydroergotamine and Sumatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 24 hours of each other. Choose one agent for each migraine episode and observe the timing interval.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Eletriptan. The full list is on the Sumatriptan page.
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