藥物交互作用
Etoricoxib + Venlafaxine
嚴重程度: 中度
Etoricoxib and Venlafaxine: moderate interaction.
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Venlafaxine and NSAIDs including selective COX-2 inhibitors such as etoricoxib each increase the risk of bleeding, and together the risk of gastrointestinal and other haemorrhage is higher. The absolute risk is modest in healthy patients but meaningful in older adults and those with prior ulcers. Etoricoxib may carry less gastric toxicity than non-selective NSAIDs but does not remove this risk.
用白話說明這項交互作用的意義
Etoricoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoricoxib belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
為什麼會發生
Venlafaxine inhibits serotonin reuptake into platelets, depleting platelet serotonin and impairing aggregation, while NSAIDs add mucosal injury and effects on haemostasis. Etoricoxib may also raise blood pressure, which venlafaxine can also do.
處置方式
Use the lowest effective etoricoxib dose for the shortest duration, and consider a PPI in patients with risk factors for GI bleeding. Monitor for bruising, melaena, haematemesis and check blood count if use is prolonged.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
- Effexor XR (venlafaxine) Prescribing Information - Warnings and Precautions: Abnormal Bleeding — FDA Label
- Arcoxia (etoricoxib) Summary of Product Characteristics — EMA SmPC
Venlafaxine 的其他交互作用
常見問題
Can I take Etoricoxib with Venlafaxine?
MediHelp rates the interaction as moderate. Etoricoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine and NSAIDs including selective COX-2 inhibitors such as etoricoxib each increase the risk of bleeding, and together the risk of gastrointestinal and other haemorrhage is higher. The absolute risk is modest in healthy patients but meaningful in older adults and those with prior ulcers. Etoricoxib may carry less gastric toxicity than non-selective NSAIDs but does not remove this risk.
How serious is the interaction between Etoricoxib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective etoricoxib dose for the shortest duration, and consider a PPI in patients with risk factors for GI bleeding. Monitor for bruising, melaena, haematemesis and check blood count if use is prolonged.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
