藥物交互作用
Etrasimod + Interferon beta 1b
嚴重程度: 嚴重
Etrasimod and Interferon beta 1b: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Etrasimod lowers circulating lymphocyte counts and interferon beta can also affect immune function and cause leukopenia. Combining them could add to immune suppression and raise the risk of infection, and this combination has not been studied. The effect of etrasimod on lymphocytes persists for some weeks after the last dose.
用白話說明這項交互作用的意義
Etrasimod and Interferon beta 1b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Interferon beta 1b belongs to Central Nervous System.
為什麼會發生
Additive immunomodulatory effects: etrasimod sequesters lymphocytes via S1P receptor modulation while interferon beta alters immune function and may reduce blood counts.
處置方式
Avoid combining these agents, including during the weeks after etrasimod is stopped. If used, monitor the complete blood count and watch closely for signs of infection.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Interferon beta 1b 的其他交互作用
Etrasimod 的其他交互作用
常見問題
Can I take Etrasimod with Interferon beta 1b?
MediHelp rates the interaction as major. Etrasimod and Interferon beta 1b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocyte counts and interferon beta can also affect immune function and cause leukopenia. Combining them could add to immune suppression and raise the risk of infection, and this combination has not been studied. The effect of etrasimod on lymphocytes persists for some weeks after the last dose.
How serious is the interaction between Etrasimod and Interferon beta 1b?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining these agents, including during the weeks after etrasimod is stopped. If used, monitor the complete blood count and watch closely for signs of infection.
What other medicines interact with Interferon beta 1b?
MediHelp also lists interactions of Interferon beta 1b with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Ciltacabtagene autoleucel. The full list is on the Interferon beta 1b page.
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