藥物交互作用
Fingolimod + Pentostatin
嚴重程度: 嚴重
Fingolimod and Pentostatin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Pentostatin causes profound lymphocyte suppression, particularly of T cells, and fingolimod also reduces circulating lymphocytes. Together they may markedly increase susceptibility to opportunistic infection.
用白話說明這項交互作用的意義
Fingolimod and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Pentostatin belongs to Oncology.
為什麼會發生
Additive immunosuppression via adenosine deaminase inhibition-mediated lymphotoxicity and lymphocyte sequestration.
處置方式
Avoid the combination where possible. If needed, monitor lymphocyte counts closely and consider antimicrobial prophylaxis.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fingolimod 的其他交互作用
Pentostatin 的其他交互作用
常見問題
Can I take Fingolimod with Pentostatin?
MediHelp rates the interaction as major. Fingolimod and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin causes profound lymphocyte suppression, particularly of T cells, and fingolimod also reduces circulating lymphocytes. Together they may markedly increase susceptibility to opportunistic infection.
How serious is the interaction between Fingolimod and Pentostatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If needed, monitor lymphocyte counts closely and consider antimicrobial prophylaxis.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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