藥物交互作用
Nelarabine + Pentostatin
嚴重程度: 嚴重
Nelarabine and Pentostatin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Pentostatin inhibits adenosine deaminase, which converts nelarabine to ara-G. Combination may alter nelarabine handling and has been associated with increased neurologic toxicity.
用白話說明這項交互作用的意義
Nelarabine and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nelarabine belongs to Oncology; Pentostatin belongs to Oncology.
為什麼會發生
Adenosine deaminase inhibition by pentostatin interferes with nelarabine metabolism and may increase neurotoxicity.
處置方式
Avoid the combination and monitor closely for neurologic toxicity if unavoidable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nelarabine 的其他交互作用
Pentostatin 的其他交互作用
常見問題
Can I take Nelarabine with Pentostatin?
MediHelp rates the interaction as major. Nelarabine and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin inhibits adenosine deaminase, which converts nelarabine to ara-G. Combination may alter nelarabine handling and has been associated with increased neurologic toxicity.
How serious is the interaction between Nelarabine and Pentostatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and monitor closely for neurologic toxicity if unavoidable.
What other medicines interact with Nelarabine?
MediHelp also lists interactions of Nelarabine with, for example, Deferiprone, Siponimod, Tofacitinib. The full list is on the Nelarabine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
