藥物交互作用
Flecainide + Thioridazine
嚴重程度: 禁忌併用
Flecainide and Thioridazine: contraindicated interaction.
最後更新
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摘要
Thioridazine markedly prolongs the QT interval, and inhibits CYP2D6, which can raise flecainide levels. The combination carries a high risk of torsades de pointes and sudden cardiac death.
用白話說明這項交互作用的意義
Flecainide and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flecainide belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation and conduction effects plus CYP2D6 inhibition by thioridazine reducing flecainide clearance.
處置方式
Do not use together; choose a different antipsychotic with lower QT liability. If a patient is already on both, stop one under cardiac monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Flecainide 的其他交互作用
Thioridazine 的其他交互作用
常見問題
Can I take Flecainide with Thioridazine?
MediHelp rates the interaction as contraindicated. Flecainide and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine markedly prolongs the QT interval, and inhibits CYP2D6, which can raise flecainide levels. The combination carries a high risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Flecainide and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different antipsychotic with lower QT liability. If a patient is already on both, stop one under cardiac monitoring.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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