藥物交互作用
Flecainide + Ritonavir
嚴重程度: 禁忌併用
Flecainide and Ritonavir: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Ritonavir can markedly raise flecainide plasma concentrations. Flecainide has a narrow therapeutic index, so higher exposure raises the risk of conduction block, ventricular proarrhythmia and other serious cardiac toxicity.
用白話說明這項交互作用的意義
Flecainide and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Flecainide belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
為什麼會發生
Ritonavir inhibits CYP2D6 (and CYP3A4), reducing the metabolic clearance of flecainide.
處置方式
Avoid the combination; labeling for ritonavir contraindicates it. Choose an alternative antiarrhythmic or antiretroviral regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Flecainide 的其他交互作用
Ritonavir 的其他交互作用
常見問題
Can I take Flecainide with Ritonavir?
MediHelp rates the interaction as contraindicated. Flecainide and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir can markedly raise flecainide plasma concentrations. Flecainide has a narrow therapeutic index, so higher exposure raises the risk of conduction block, ventricular proarrhythmia and other serious cardiac toxicity.
How serious is the interaction between Flecainide and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling for ritonavir contraindicates it. Choose an alternative antiarrhythmic or antiretroviral regimen.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
