藥物交互作用
Fluconazole + Selumetinib
嚴重程度: 嚴重
Fluconazole and Selumetinib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Fluconazole can raise selumetinib levels, increasing risks such as gastrointestinal toxicity, rash, and cardiomyopathy. Selumetinib is metabolized mainly by CYP3A4.
用白話說明這項交互作用的意義
Fluconazole and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Selumetinib belongs to Oncology.
為什麼會發生
Fluconazole inhibits CYP3A4 metabolism of selumetinib.
處置方式
Avoid if possible; if unavoidable, reduce the selumetinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluconazole 的其他交互作用
Selumetinib 的其他交互作用
常見問題
Can I take Fluconazole with Selumetinib?
MediHelp rates the interaction as major. Fluconazole and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole can raise selumetinib levels, increasing risks such as gastrointestinal toxicity, rash, and cardiomyopathy. Selumetinib is metabolized mainly by CYP3A4.
How serious is the interaction between Fluconazole and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce the selumetinib dose per labeling and monitor for adverse effects. Resume the prior dose after the inhibitor has been stopped for about three half-lives.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
