藥物交互作用
Folic acid + Pyrimethamine
嚴重程度: 中度
Folic acid and Pyrimethamine: moderate interaction.
最後更新
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摘要
Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
用白話說明這項交互作用的意義
Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
為什麼會發生
Pharmacodynamic antagonism, as folic acid supplies the folate end-product whose synthesis pyrimethamine blocks.
處置方式
Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pyrimethamine 的其他交互作用
Folic acid 的其他交互作用
常見問題
Can I take Folic acid with Pyrimethamine?
MediHelp rates the interaction as moderate. Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
How serious is the interaction between Folic acid and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
