藥物交互作用
Fosphenytoin + Pyrimethamine
嚴重程度: 中度
Fosphenytoin and Pyrimethamine: moderate interaction.
最後更新
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摘要
Pyrimethamine is an antifolate and phenytoin (the active form of fosphenytoin) can also lower folate status. Together they may add to folate deficiency and haematological toxicity. Reports of reduced anticonvulsant effect are inconsistent.
用白話說明這項交互作用的意義
Fosphenytoin and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosphenytoin belongs to Central Nervous System; Pyrimethamine belongs to Anti Parasitic.
為什麼會發生
Additive folate antagonism; pyrimethamine inhibits dihydrofolate reductase and phenytoin impairs folate handling, and phenytoin levels may also change through unclear mechanisms.
處置方式
Monitor complete blood counts and seizure control, and check phenytoin concentrations if control changes. Give folinic acid with pyrimethamine as usually recommended.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pyrimethamine 的其他交互作用
Fosphenytoin 的其他交互作用
常見問題
Can I take Fosphenytoin with Pyrimethamine?
MediHelp rates the interaction as moderate. Fosphenytoin and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine is an antifolate and phenytoin (the active form of fosphenytoin) can also lower folate status. Together they may add to folate deficiency and haematological toxicity. Reports of reduced anticonvulsant effect are inconsistent.
How serious is the interaction between Fosphenytoin and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and seizure control, and check phenytoin concentrations if control changes. Give folinic acid with pyrimethamine as usually recommended.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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