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藥物交互作用

Fosphenytoin + Ranolazine

嚴重程度: 禁忌併用

Fosphenytoin and Ranolazine: contraindicated interaction.

最後更新

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Phenytoin, formed from fosphenytoin, is a strong CYP3A4 inducer and can substantially lower ranolazine levels, causing loss of antianginal effect. Ranolazine labeling contraindicates CYP3A inducers.

用白話說明這項交互作用的意義

Fosphenytoin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fosphenytoin belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.

證據等級: High

為什麼會發生

Induction of CYP3A4 (and P-gp) increases ranolazine clearance.

處置方式

Avoid the combination and choose another antianginal. Use a different anticonvulsant if the patient needs ranolazine.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Fosphenytoin 與 Ranolazine 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Fosphenytoin with Ranolazine?

MediHelp rates the interaction as contraindicated. Fosphenytoin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin, formed from fosphenytoin, is a strong CYP3A4 inducer and can substantially lower ranolazine levels, causing loss of antianginal effect. Ranolazine labeling contraindicates CYP3A inducers.

How serious is the interaction between Fosphenytoin and Ranolazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antianginal. Use a different anticonvulsant if the patient needs ranolazine.

What other medicines interact with Ranolazine?

MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.

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