藥物交互作用
Fosphenytoin + Lurasidone
嚴重程度: 禁忌併用
Fosphenytoin and Lurasidone: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer that can reduce lurasidone exposure dramatically. This may lead to loss of antipsychotic efficacy and relapse. Strong inducers are contraindicated with lurasidone.
用白話說明這項交互作用的意義
Fosphenytoin and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fosphenytoin belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
為什麼會發生
Induction of CYP3A4 by phenytoin increases lurasidone clearance.
處置方式
Avoid the combination; use an alternative anticonvulsant or an antipsychotic not dependent on CYP3A4, and monitor psychiatric status.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lurasidone 的其他交互作用
Fosphenytoin 的其他交互作用
常見問題
Can I take Fosphenytoin with Lurasidone?
MediHelp rates the interaction as contraindicated. Fosphenytoin and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer that can reduce lurasidone exposure dramatically. This may lead to loss of antipsychotic efficacy and relapse. Strong inducers are contraindicated with lurasidone.
How serious is the interaction between Fosphenytoin and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative anticonvulsant or an antipsychotic not dependent on CYP3A4, and monitor psychiatric status.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
