藥物交互作用
Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir
嚴重程度: 禁忌併用
Fosphenytoin and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Fosphenytoin is metabolized to phenytoin, a potent inducer of CYP3A4 and P-gp. It can substantially lower concentrations of sofosbuvir, velpatasvir and voxilaprevir. This risks HCV treatment failure.
用白話說明這項交互作用的意義
Fosphenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fosphenytoin belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
為什麼會發生
Phenytoin induces CYP3A4, CYP2B6 and P-gp, which increases clearance of the HCV drugs.
處置方式
Do not coadminister; switch to a non-inducing anticonvulsant such as levetiracetam, or defer HCV therapy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sofosbuvir-velpatasvir-voxilaprevir 的其他交互作用
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort 禁忌併用
Fosphenytoin 的其他交互作用
常見問題
Can I take Fosphenytoin with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Fosphenytoin and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosphenytoin is metabolized to phenytoin, a potent inducer of CYP3A4 and P-gp. It can substantially lower concentrations of sofosbuvir, velpatasvir and voxilaprevir. This risks HCV treatment failure.
How serious is the interaction between Fosphenytoin and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; switch to a non-inducing anticonvulsant such as levetiracetam, or defer HCV therapy.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Phenobarbital, Phenytoin, Primidone. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
