藥物交互作用
Gefitinib + Phenytoin
嚴重程度: 嚴重
Gefitinib and Phenytoin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Phenytoin strongly induces CYP3A4 and can substantially lower gefitinib exposure. This may reduce antitumor efficacy in EGFR-mutated lung cancer.
用白話說明這項交互作用的意義
Gefitinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Phenytoin belongs to Central Nervous System.
為什麼會發生
CYP3A4 induction by phenytoin accelerates the metabolism of gefitinib.
處置方式
Prefer an alternative anticonvulsant without enzyme induction. If unavoidable, increase gefitinib to 500 mg daily and return to 250 mg about 7 days after phenytoin is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Phenytoin 的其他交互作用
Gefitinib 的其他交互作用
常見問題
Can I take Gefitinib with Phenytoin?
MediHelp rates the interaction as major. Gefitinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin strongly induces CYP3A4 and can substantially lower gefitinib exposure. This may reduce antitumor efficacy in EGFR-mutated lung cancer.
How serious is the interaction between Gefitinib and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative anticonvulsant without enzyme induction. If unavoidable, increase gefitinib to 500 mg daily and return to 250 mg about 7 days after phenytoin is stopped.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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