藥物交互作用
Gefitinib + Lansoprazole
嚴重程度: 嚴重
Gefitinib and Lansoprazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Gefitinib needs an acidic stomach for adequate dissolution, and sustained gastric pH elevation lowers gefitinib exposure. This may compromise its efficacy in EGFR-mutant lung cancer.
用白話說明這項交互作用的意義
Gefitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Gastric pH elevation reduces gefitinib solubility and absorption.
處置方式
Avoid PPIs if possible. If a PPI is essential, give gefitinib 12 hours after the PPI dose, though acid-reducing effects may persist.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lansoprazole 的其他交互作用
Gefitinib 的其他交互作用
常見問題
Can I take Gefitinib with Lansoprazole?
MediHelp rates the interaction as major. Gefitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib needs an acidic stomach for adequate dissolution, and sustained gastric pH elevation lowers gefitinib exposure. This may compromise its efficacy in EGFR-mutant lung cancer.
How serious is the interaction between Gefitinib and Lansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If a PPI is essential, give gefitinib 12 hours after the PPI dose, though acid-reducing effects may persist.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
