藥物交互作用
Gefitinib + Omeprazole
嚴重程度: 嚴重
Gefitinib and Omeprazole: major interaction.
最後更新
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摘要
Gefitinib absorption depends on gastric acidity, and raising gastric pH substantially lowers its exposure. This may reduce anti-tumour efficacy.
用白話說明這項交互作用的意義
Gefitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Omeprazole raises gastric pH, decreasing gefitinib solubility and absorption.
處置方式
Avoid PPIs if possible. If one is needed, take gefitinib 12 hours after the PPI dose, though H2 antagonists or antacids with timed separation are preferable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Omeprazole 的其他交互作用
Gefitinib 的其他交互作用
常見問題
Can I take Gefitinib with Omeprazole?
MediHelp rates the interaction as major. Gefitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib absorption depends on gastric acidity, and raising gastric pH substantially lowers its exposure. This may reduce anti-tumour efficacy.
How serious is the interaction between Gefitinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If one is needed, take gefitinib 12 hours after the PPI dose, though H2 antagonists or antacids with timed separation are preferable.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
