藥物交互作用
Carbamazepine + Gefitinib
嚴重程度: 嚴重
Carbamazepine and Gefitinib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Carbamazepine markedly lowers gefitinib exposure and may reduce antitumor efficacy.
用白話說明這項交互作用的意義
Carbamazepine and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Gefitinib belongs to Oncology.
為什麼會發生
Carbamazepine induces CYP3A4, increasing gefitinib clearance.
處置方式
Prefer an alternative anticonvulsant; if unavoidable, increase gefitinib to 500 mg daily and return to 250 mg 7 days after stopping carbamazepine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbamazepine 的其他交互作用
Gefitinib 的其他交互作用
常見問題
Can I take Carbamazepine with Gefitinib?
MediHelp rates the interaction as major. Carbamazepine and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine markedly lowers gefitinib exposure and may reduce antitumor efficacy.
How serious is the interaction between Carbamazepine and Gefitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative anticonvulsant; if unavoidable, increase gefitinib to 500 mg daily and return to 250 mg 7 days after stopping carbamazepine.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
